CTD1-CTD2-CH-CD-SH-HR2
The CTD1 is part of the spike protein and plays a role in the overall structure and stability of the protein. It can be involved in receptor binding and may influence the conformational changes necessary for fusion.
Similar to CTD1, the CTD2 contributes to the structural integrity of the spike protein. It may also have roles in receptor interactions and the stability of the spike protein during the fusion process.
The central helix (CH) connects the heptad repeat regions (HR1 and HR2) and is important for maintaining the stability of the six-helix bundle structure that forms during the fusion of the viral and host membranes.
The connector domain (TM) is crucial for linking different parts of the spike protein together. It helps facilitate the interactions between the heptad repeat regions (HR1 and HR2), which are essential for the fusion process.
HR2 contains repeating sequences of seven amino acids and interacts with HR1 to form the six-helix bundle structure during the fusion process. It plays a critical role in bringing the viral and host membranes close together for fusion.
| № | Extended PDB ID | PDB ID | Method | Resolution | Chain | Start | End | Macromolecules |
|---|---|---|---|---|---|---|---|---|
| 1 | pdb_00008thf | 8THF | EM | 2.83 A | A/B/C | 525 | 1211 | Spike protein S1, Spike glycoprotein |