CH
CH (central helix) is a structural element of the coronavirus spike (S) protein located in the S2 subunit. The central helix is an α-helical segment that plays a key role in the fusion process between the viral envelope and the host cell membrane.
The CH participates in conformational changes of the S protein that occur after the virus binds to the receptor (e.g., ACE2) and undergoes proteolytic activation. These changes lead to the transition of the S protein into a post-fusion state, in which the CH, together with other elements, forms a stable structure that facilitates the close apposition and fusion of the viral and cellular membranes.
| № | Extended PDB ID | PDB ID | Method | Resolution | Chain | Start | End | Macromolecules | Ligand 1 | Ligand 2 | Ligand 3 | Ligand 4 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | pdb_00007n1b | 7N1B | X-ray | 2.81 A | C/F | 1000 | 1008 | Spike protein S2 | MHC class I antigen, A-2 alpha chain | Beta-2-microglobulin | - | - |
| 2 | pdb_00007n1e | 7N1E | X-ray | 2.30 A | C | 1000 | 1008 | Spike protein S2 | MHC class I antigen, A-2 alpha chain | Beta-2-microglobulin | pRLQ3 T cell receptor alpha chain | pRLQ3 T cell receptor beta chain |
| 3 | pdb_00008gom | 8GOM | X-ray | 2.78 A | C | 1000 | 1008 | Spike protein S2 | MHC class I antigen | SARS-CoV-2 specific private TCR RLQ7 beta | Beta-2-microglobulin | SARS-CoV-2 specific private TCR RLQ7 alpha |
| 4 | pdb_00008gon | 8GON | X-ray | 2.60 A | C | 1000 | 1008 | Spike protein S2 | MHC class I antigen | Beta-2-microglobulin | SARS-CoV-2 specific private TCR RLQ7 alpha | SARS-CoV-2 specific private TCR RLQ7 beta |